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SE03 - From glia cell functions to brain dysfunctions: understanding the cellular roots of brain disorders (09:45-11:15)

Goal of this Satellite symposium is to bring together scientists who use different methodological approaches for a better understanding of glial functions to ultimately identify glial-specific molecular signals indicative of selected physiological or pathological states or molecular effectors of cell reprogramming, which may support the development of pharmacological/replacement therapies.


July 7, 2022 - 9:30 am


July 7, 2022 - 5:45 pm


Hôpital Pitié 47 Bd de l'Hôpital 75013 Paris   View map

In the Central Nervous System, astrocytes represent bridging elements between parenchymal and vascular compartments, thereby forming a functional unit (neurovascular, NVU) that might “sense” the brain state, adapt its molecular profile and secrete factors in the bloodstream as a reflection of this state. Moreover, astrocytes modulate astrocyte-to-neuron communication, thereby enabling nerve cells to acquire and store information through learning processes. The discovery of direct reconversion of glia cells into neurons has additionally provided novel insights into the generation of fully functional mature neurons from other cell types, with the potential to develop alternative therapeutic approaches for neurodegenerative brain disorders.
Thus, astrocyte-specific molecular prints may become useful biomarkers of distinct cellular (dys)functions in health and disease. In a translational perspective, their characterization in pathological conditions may support the development of diagnostic tools or the selection of tailored treatment options for individual patients. Finally, glia cell reprogramming may offer valid, less invasive, cell replacement therapies for human disorders.

Register by writing to: Barbara Di Benedetto – Barbara.Di-Benedetto@ukr.de / Eugenia Vivi – Eugenia.Vivi@ukr.de

More info at: https://www.uni-regensburg.de/research/grk-emotion/news/index.html